COMBINATORIAL EFFECTS OF ENVIRONMENTAL PARAMETERS ON TRANSCRIPTIONAL REGULATION IN SACCHAROMYCES CEREVISIAE: A QUANTITATIVE ANALYSIS OF A COMPENDIUM OF CHEMOSTAT-BASED TRANSCRIPTOME DATA

Abstract Background Microorganisms adapt their transcriptome by integrating multiple chemical and physical signals from their environment.Shake-flask cultivation does not allow precise manipulation of individual culture parameters and therefore precludes a quantitative analysis of the (combinatorial) influence of these parameters on transcriptional

Objective Immunotherapy has not yielded satisfactory therapeutic responses in gastric cancer (GC).However, targeting myeloid checkpoints holds promise for expanding the potential of immunotherapy.This study aims to evaluate the critical role of Siglec-10+ tumor-associated macrophages (TAMs) in regulating antitumor immunity and to explore the potent

The negative effects of tourism in mature destinations is a central debate in academia and everyday public life.The rise of tourism in the city of Barcelona was originally driven by the 1992 Olympic Games, which put it on the map of potential destinations of interest.Since then, the number of international visitors has increased year after year.Thi